Fri Apr 15 2022

38 articles - From Saturday Apr 09 2022 to Friday Apr 15 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Pancreas

Current Evidence in the Management of Premalignant Cystic Lesions of the Pancreas in Patients Undergoing Liver Transplantation.

Six patients (0.9%) underwent pancreatic resection, post-OLT, for suspected "worrisome features" on imaging. One death was due to pancreatic-related cancer, post-OLT. Based on the review, the authors suggest the following: (1) patients with pPCLs undergoing OLT, without "worrisome features," should be followed conservatively; (2) presence of pPCLs alone should not preclude eligibility for OLT, nor should chronic immunosuppression be altered; (3) follow-up should parallel standard approach applied in immunocompetent patients, as development of "worrisome features" of cancer is rare and does not appear to be hastened by immunosuppression; (4) resection is recommended for surgically fit patients without portal hypertension that develop "worrisome features."

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Outpatient Pain Management in Children With Chronic Pancreatitis: A Scoping Systematic Review.

No therapy had sufficient high-quality studies to warrant untempered, evidence-based support for use in children with CP. Multicenter studies are needed to identify pain management "best practices."

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Associations of lower-carbohydrate and lower-fat diets with mortality among people with prediabetes.

The multivariate-adjusted HRs (95% CIs) of all-cause mortality per 20-percentile increment in dietary scores were 0.88 (0.80, 0.96) for healthy LCD score (P = 0.003), 0.85 (0.78, 0.93) for healthy LFD score (P < 0.001), 1.09 (0.99, 1.21) for unhealthy LCD score (P = 0.08), and 1.11 (1.00, 1.22) for unhealthy LFD score (P = 0.05). Isocalorically replacing 3%-5% energy of low-quality carbohydrate or saturated fat with high-quality carbohydrate, plant-based protein, or unsaturated fat was associated with a 14%-37% reduced all-cause mortality. Healthy LCD and LFD scores were significantly associated with lower all-cause mortality, whereas unhealthy LCD and LFD scores tended to be associated with higher all-cause mortality, among people with prediabetes.

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Breastfeeding duration modifies the association between maternal weight status and offspring dietary palmitate oxidation.

Higher 2-yo-DPO in offspring of women with EW vs NW were driven by BF duration. Higher HM insulin and leptin concentrations in women with EW may explain these finding. More studies are needed to confirm these results ClinicalTrials.gov Identifier NCT03281850.

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Effectiveness of an integrated agriculture, nutrition-specific and nutrition-sensitive program on child growth in Western Kenya: a cluster-randomized controlled trial.

We found a slightly stronger effect in the per-protocol analysis (0.15 (0.06, 0.24)). Dietary diversity and consumption of iron-rich foods were improved in the intervention group and reported fever, lower respiratory tract infection and diarrheal episodes were lower in the intervention group. This study found a modest improvement in linear growth, indicating the need for multiple integrated interventions to achieve benefit.

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Higher vitamin B6 status is associated with improved survival among patients with stage I-III colorectal cancer.

Higher preoperative vitamin B6 status is associated with improved OS among stage I-III CRC patients.

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Sources of dietary gluten in the first two years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children: TEDDY study.

A high daily intake of bread at age 12 months and milk cereal drink during the second year in life is associated with increased risk of both celiac disease autoimmunity and celiac disease in genetically at-risk children.

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Liver Transpl

Operational tolerance is not always permanent: A 10-year prospective study in pediatric liver transplant recipients.

Populations of T regulatory cells (%CD4+ CD25hi CD127lo) were significantly higher in patients with tolerance (p=0.02). Our results emphasize that spontaneous operational tolerance is a dynamic and non-permanent state. It is therefore essential for patients who are clinically stable off immunosuppression to undergo regular follow-up and laboratory monitoring, as well as surveillance biopsies to rule out sub-clinical rejection.

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Pancreas

Auditing Management of Acute Pancreatitis Using Comprehensive Quality Indicators.

We show that these quality indicators can be used to audit the management of acute pancreatitis in specific management domains.

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Celiac Plexus Neurolysis Is Associated With Decreased Survival in Patients With Pancreatic Cancer: A Propensity Score Analysis.

Pancreatic cancer patients who underwent CPN had decreased survival compared with opioid users. This suggests that opioid sparing methods to reduce pancreatic cancer pain may actually be harmful. Future prospective studies should investigate whether other opioid sparing therapies impact pancreatic cancer survival.

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Clinicopathological Characteristics of Gastroenteropancreatic Neuroendocrine Tumors: 10 Years of Experience From a Single Center.

They are increasing in frequency and are the most common tumors in the pancreas. Nonfunctional tumors made up the majority of cases. The main treatment was surgical resection. Histological grade and TNM stage are independent prognostic factors.

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Clinicopathological Significance of BRCAness in Resectable Pancreatic Ductal Adenocarcinoma and Its Association With Anticancer Drug Sensitivity in Pancreatic Cancer Cells.

Our results revealed that a considerable number of PDACs are positive for BRCAness, suggesting that BRCAness status could be a useful biomarker for selecting anticancer treatments for advanced or relapsed PDAC.

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Development of a Score for Predicting Severe Acute Pancreatitis at Admission.

The ASAP score demonstrates remarkable predictive accuracy in distinguishing severe forms of acute pancreatitis.

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Extrapancreatic Complications in Hospitalized Patients With Mild Acute Pancreatitis Are Associated With Poorer Outcomes: Results From a Single-Center Study.

The EPCs are common among noncritical AP patients and contribute to poor outcomes like increased LOS and 30-day readmissions.

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HDAC4 Mediates Smoking-Induced Pancreatic Cancer Metastasis.

We found that HDAC4 is the only HDAC induced by smoking among al HDACs analyzed. We found that smoking promotes invasion and metastasis of PDAC cells through a mechanism that involves HDAC4 and that HDAC4 is a promising target for preventing PDAC metastasis.

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Pancreatic Stones: Clinical Outcomes With Nonsurgical Treatment in a Japanese Single-Center Study.

Nonsurgical stone removal usually improved symptoms and preserved pancreatic exocrine function. Nonsurgical treatment with extracorporeal shock wave lithotripsy followed by endoscopic treatment if needed is useful as initial management for pancreatolithiasis.

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Resection Prolongs Overall Survival for Nonmetastatic Midgut Small Bowel Neuroendocrine Tumors: A National Cancer Data Base Study.

To our knowledge, this is the first national study to evaluate survival after RS for nonmetastatic SBNETs. Results suggest that RS of SBNETs may prolong 5-year survival.

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Sarcopenia: Prognostic Value for Unresectable Pancreatic Ductal Adenocarcinoma Patients Treated With Gemcitabine Plus Nab-Paclitaxel.

Sarcopenia diagnosed by L3-SMI is a prognostic factor in elderly patients who receive GnP for unresectable PDAC. However, GnP exhibits a certain efficacy in sarcopenia and nonsarcopenia patients.

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Survival Impact of Perioperative Red Blood Cell Transfusion During Pancreatectomy in Patients With Pancreatic Ductal Adenocarcinoma: A Propensity Score Matching Analysis.

Our results show that PBT has no survival impact in patients who underwent pancreatectomy for pancreatic ductal adenocarcinoma.

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Validation of the Enriching New-Onset Diabetes for Pancreatic Cancer Model: A Retrospective Cohort Study Using Real-World Data.

Our findings support the robustness, generalizability and clinical applicability of the END-PAC model.

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Pancreatology

Longitudinal changes of serum protein N-Glycan levels for earlier detection of pancreatic cancer in high-risk individuals.

Serum N-glycan monitoring may support early detection in a pancreas surveillance program.

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Pancreatic CT density is an optimal imaging biomarker for earlier detection of malignancy in the pancreas with intraductal papillary mucinous neoplasm.

Decreasing PI would be an optimal imaging biomarker for earlier detection of malignancies in the pancreas with IPMN.

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Selection of parenchymal preserving or total pancreatectomy with/without islet cell autotransplantation surgery for patients with chronic pancreatitis.

The most appropriate selection of surgery based on the algorithm yields good and comparable outcomes.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Pancreas

The Role of Estrogen Signaling in Cellular Iron Metabolism in Pancreatic ß Cells.

In this context, pancreatic ß cells express considerable levels of conventional E2 receptors (ERs; mainly ER-a) and nonconventional G protein-coupled estrogen receptors and hence responsive to E2 signals. Moreover, pancreatic islet cells require significant amounts of iron for proper functioning, replication and survival and, hence, well equipped to manage cellular iron metabolism (acquisition, utilization, storage, and release). In this review, we examine the link between E2 and cellular iron metabolism in pancreatic ß cells and discuss the bearing of such a link on ß-cell survival and function.

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Letters&Replies

Letters to the editors and authors’ replies

Liver Transpl

A standardized immunosuppressive regimen for liver transplanted patients treated by Atezolizumab-Bevacizumab to avoid graft rejection?

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Others

all remaining publications eg case reports, images of the month, etc…

Liver Transpl

Outcomes of Liver Transplantation in Recipients with Previous COVID-19 Infection.

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Pancreas

Gastric Tube-Preserving Pancreaticoduodenectomy Using Intraoperative Blood Perfusion Imaging After Esophagectomy.

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Isolated Intraductal Papillary Mucinous Tumor Arising in the Santorini's Duct With Malignant Transformation.

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Memorial Tribute to Paul D. Webster, III, MD.

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Menstruation-Associated Pancreatitis in a Perimenopausal Woman.

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Mixed Serous Cell Neuroendocrine Neoplasm of the Pancreas, Demonstrating a Biphasic Developmental Origin, Identified Through Genomic Mutational Analysis.

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Pancreaticoduodenectomy in a Patient With Marfan Syndrome.

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Predicting Clinical Severity in Acute Pancreatitis: Addressing the Admission Dilemma.

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Quantitative Evidence for Early Metastasis in a Pancreatic Acinar Cell Carcinoma Patient.

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Real-World, Retrospective Data of Pancreatic Cancer Treatment Outcomes.

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Risk Factors of Atherosclerotic Celiac Artery Stenosis Among Patients Undergoing Pancreaticoduodenectomy.

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The Strange Case of a Pancreatic Neuroendocrine Carcinoma With Low Proliferation Index and Atypical Clinical Behavior.

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Why Do Small Intraductal Papillary Mucinous Neoplasms Create Such a Huge Management Challenge?: How International Classification of Diseases Codes Have Failed Us.

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